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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TYK2 All Species: 8.48
Human Site: S406 Identified Species: 20.74
UniProt: P29597 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29597 NP_003322.3 1187 133650 S406 D N K C L E L S L P S R A A A
Chimpanzee Pan troglodytes Q5IS37 825 92786 F161 E L Q L E Q N F F N C S C D I
Rhesus Macaque Macaca mulatta XP_001101130 1120 124474 S406 D N K C L E L S L P S R A A A
Dog Lupus familis XP_533918 1861 202919 T458 D N K S L E L T L P S R A M A
Cat Felis silvestris
Mouse Mus musculus Q9R117 1180 132809 C401 D N K C L L L C L C S Q A E A
Rat Rattus norvegicus Q62689 1132 130567 E355 D G K V L E I E L S S L K E A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q75R65 1129 129828 E353 D S K N L E A E F Q S L R E A
Frog Xenopus laevis NP_001085663 1179 135311 A401 D N R C L E I A L P S C E D A
Zebra Danio Brachydanio rerio O12990 1153 132463 D391 D N K T M E L D L F Y R D A A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24592 1177 135043 Q389 L P K G Y E M Q F Q T E K E M
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 21 82.1 52.7 N.A. 79.5 38.4 N.A. N.A. 38.1 58.9 45.6 N.A. 22.9 N.A. N.A. N.A.
Protein Similarity: 100 36.9 85.7 57.1 N.A. 86.6 55.5 N.A. N.A. 55.2 74.1 62.7 N.A. 38.7 N.A. N.A. N.A.
P-Site Identity: 100 0 100 80 N.A. 66.6 46.6 N.A. N.A. 40 60 60 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 20 100 86.6 N.A. 73.3 53.3 N.A. N.A. 46.6 80 66.6 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 10 10 0 0 0 0 40 30 80 % A
% Cys: 0 0 0 40 0 0 0 10 0 10 10 10 10 0 0 % C
% Asp: 80 0 0 0 0 0 0 10 0 0 0 0 10 20 0 % D
% Glu: 10 0 0 0 10 80 0 20 0 0 0 10 10 40 0 % E
% Phe: 0 0 0 0 0 0 0 10 30 10 0 0 0 0 0 % F
% Gly: 0 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 20 0 0 0 0 0 0 0 10 % I
% Lys: 0 0 80 0 0 0 0 0 0 0 0 0 20 0 0 % K
% Leu: 10 10 0 10 70 10 50 0 70 0 0 20 0 0 0 % L
% Met: 0 0 0 0 10 0 10 0 0 0 0 0 0 10 10 % M
% Asn: 0 60 0 10 0 0 10 0 0 10 0 0 0 0 0 % N
% Pro: 0 10 0 0 0 0 0 0 0 40 0 0 0 0 0 % P
% Gln: 0 0 10 0 0 10 0 10 0 20 0 10 0 0 0 % Q
% Arg: 0 0 10 0 0 0 0 0 0 0 0 40 10 0 0 % R
% Ser: 0 10 0 10 0 0 0 20 0 10 70 10 0 0 0 % S
% Thr: 0 0 0 10 0 0 0 10 0 0 10 0 0 0 0 % T
% Val: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _